The big idea: Some membrane proteins and lipids carry short carbohydrate chains. The chains always face the outside of the cell, where other cells can meet them.
The points to remember
- A glycoprotein is a protein with a carbohydrate chain attached.
- A glycolipid is a lipid with a carbohydrate chain attached, in the outer layer of the bilayer.
- The carbohydrate chains are always on the extracellular side: the outside of the cell.
- Their pattern differs between cell types and between people, so cells can be recognised.
- They also help cells stick together (cell adhesion) in tissues.
Remember it as: Sugar on the outside: a name tag and a handshake.
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The big idea: Carbohydrate chains are read by other cells: they say what kind of cell this is, and let cells bind to each other.
Cell recognition
- Other cells' proteins fit the chains
- Immune cells tell 'self' from 'non-self'
- Blood groups depend on these chains
Cell adhesion
- Chains bind matching molecules on a neighbour
- Holds cells together in tissues
- Lets a sperm attach to an egg
Real example: sperm and egg: The coat around a mammal's egg contains a glycoprotein (ZP3). Sperm of the same species recognise its carbohydrate chains and bind to them; sperm of other species usually cannot.
Because the chains are outside the cell, they can only work at the surface: they meet the cell's neighbours and anything in the fluid around it.
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How it is asked: Paper 1A shows a membrane diagram and asks which part allows cell recognition. Paper 2 can ask for the structure and role of glycoproteins or glycolipids.
Outline the role of glycoproteins in the plasma membranes of white blood cells.
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