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NotesBiologyTopic 2.3Structure and function of glycoproteins and glycolipids
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2.3.93 min read

Structure and function of glycoproteins and glycolipids

IB Biology · Unit 2

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Contents

  1. 1Carbohydrate chains on proteins and lipids
  2. 2Recognition and adhesion
  3. 3Exam-style question (step by step)
The big idea: Some membrane proteins and lipids carry short carbohydrate chains. The chains always face the outside of the cell, where other cells can meet them.

The points to remember

  • A glycoprotein is a protein with a carbohydrate chain attached.
  • A glycolipid is a lipid with a carbohydrate chain attached, in the outer layer of the bilayer.
  • The carbohydrate chains are always on the extracellular side: the outside of the cell.
  • Their pattern differs between cell types and between people, so cells can be recognised.
  • They also help cells stick together (cell adhesion) in tissues.
Remember it as: Sugar on the outside: a name tag and a handshake.
A phospholipid bilayer with a glycoprotein carrying a short branched carbohydrate chain and a glycolipid in the outer layer with its own chain; all chains point outside; a protein from another cell recognises a chain
Glycoproteins and glycolipids: chains on the outside.

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The big idea: Carbohydrate chains are read by other cells: they say what kind of cell this is, and let cells bind to each other.

Cell recognition

  • Other cells' proteins fit the chains
  • Immune cells tell 'self' from 'non-self'
  • Blood groups depend on these chains

Cell adhesion

  • Chains bind matching molecules on a neighbour
  • Holds cells together in tissues
  • Lets a sperm attach to an egg
Real example: sperm and egg: The coat around a mammal's egg contains a glycoprotein (ZP3). Sperm of the same species recognise its carbohydrate chains and bind to them; sperm of other species usually cannot.

Because the chains are outside the cell, they can only work at the surface: they meet the cell's neighbours and anything in the fluid around it.

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How it is asked: Paper 1A shows a membrane diagram and asks which part allows cell recognition. Paper 2 can ask for the structure and role of glycoproteins or glycolipids.
IB-style questionOutline[2 marks]

Outline the role of glycoproteins in the plasma membranes of white blood cells.

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the name of the membrane component that carries a carbohydrate chain on the outer surface and is responsible for cell recognition. [1 mark]

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2.1.1Chemical properties of carbon that allow diverse compounds2.1.2Production of macromolecules by condensation reactions2.1.3Digestion of polymers into monomers by hydrolysis reactions2.1.4Form and function of monosaccharides
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