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NotesBiology HLTopic 3.2Differences between lipids and carbohydrates as respiratory substrates
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3.2.173 min read

Differences between lipids and carbohydrates as respiratory substrates (Biology HL)

IB Biology · Unit 3

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Contents

  1. 1Lipids and carbohydrates: Higher Level only
  2. 2Lipids and carbohydrates as fuel
  3. 3Exam-style question (step by step)
Lipids and carbohydrates: Higher Level only: This statement is Higher Level only. It compares the two main fuels of respiration (SL 3.2.4 names them).

Practise this as you read

  • Distinguish between lipids and carbohydrates as substrates.
  • Explain why lipids yield more energy per gram.

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The big idea: Both lipids and carbohydrates can be respired, but differently. Glucose goes through glycolysis, so it can be respired with or without oxygen. Fatty acids are cut into two-carbon acetyl groups that enter the Krebs cycle, so they need oxygen. Per gram, lipids release about twice the energy.
Glucose passing through glycolysis to pyruvate and acetyl coenzyme A, with anaerobic respiration possible; fatty acids cut into two-carbon acetyl groups joining acetyl coenzyme A, aerobic only; bars of energy per gram, about 17 for carbohydrate and about 37 kilojoules for lipid; lipids have more hydrogen per carbon
Lipids and carbohydrates, step by step.

The points to remember

  • Carbohydrate (glucose): glycolysis → pyruvate; can be respired anaerobically.
  • Lipid: fatty acids → two-carbon acetyl groups → acetyl coenzyme A → Krebs cycle.
  • Fatty acids miss glycolysis, so they can be respired only aerobically.
  • Energy per gram: lipid ≈ 37 kJ, carbohydrate ≈ 17 kJ.
  • Lipids have more hydrogen, less oxygen per carbon: more reduced NAD, more ATP.
Remember it as: Fat: twice the energy, but only with oxygen.

Real example: marathon runners and sprinters. In a marathon, muscles burn a high proportion of fat aerobically; in a sprint, they depend on glucose, which glycolysis can use quickly even without enough oxygen.

Trap: Lipids give more energy per gram, but carbohydrates are quicker to use and can give ATP without oxygen.

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How it is asked: Expect a Distinguish or Compare question on lipids and carbohydrates as respiratory substrates.
IB-style questionDistinguish[3 marks]

Distinguish between lipids and carbohydrates as respiratory substrates.

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why lipids release more energy per gram than carbohydrates when respired. [2 marks]

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