Lipids and carbohydrates: Higher Level only: This statement is Higher Level only. It compares the two main fuels of respiration (SL 3.2.4 names them).
Practise this as you read
- Distinguish between lipids and carbohydrates as substrates.
- Explain why lipids yield more energy per gram.
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The big idea: Both lipids and carbohydrates can be respired, but differently. Glucose goes through glycolysis, so it can be respired with or without oxygen. Fatty acids are cut into two-carbon acetyl groups that enter the Krebs cycle, so they need oxygen. Per gram, lipids release about twice the energy.
The points to remember
- Carbohydrate (glucose): glycolysis → pyruvate; can be respired anaerobically.
- Lipid: fatty acids → two-carbon acetyl groups → acetyl coenzyme A → Krebs cycle.
- Fatty acids miss glycolysis, so they can be respired only aerobically.
- Energy per gram: lipid ≈ 37 kJ, carbohydrate ≈ 17 kJ.
- Lipids have more hydrogen, less oxygen per carbon: more reduced NAD, more ATP.
Remember it as: Fat: twice the energy, but only with oxygen.
Real example: marathon runners and sprinters. In a marathon, muscles burn a high proportion of fat aerobically; in a sprint, they depend on glucose, which glycolysis can use quickly even without enough oxygen.
Trap: Lipids give more energy per gram, but carbohydrates are quicker to use and can give ATP without oxygen.
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How it is asked: Expect a Distinguish or Compare question on lipids and carbohydrates as respiratory substrates.
Distinguish between lipids and carbohydrates as respiratory substrates.
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