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NotesBiology HLTopic 4.1DNA replication as production of exact copies of DNA with identical base sequences
Back to Biology HL Topics
4.1.14 min read

DNA replication as production of exact copies of DNA with identical base sequences (Biology HL)

IB Biology · Unit 4

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Contents

  1. 1Exact copies at Higher Level
  2. 2Exact copies of DNA
  3. 3Why cells copy their DNA
  4. 4Exam-style question (step by step)
Exact copies at Higher Level: The same statement as SL. At HL it is the start of a longer story: how the copy is made, strand by strand, and how mistakes are caught.

Practise this as you read

  • Outline why replication is needed for growth, tissue replacement and reproduction.
  • Explain why the copies must have identical base sequences.

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The big idea: DNA replication copies one DNA molecule to make two. Both have exactly the same base sequence as the original.

The points to remember

  • Replication turns one DNA molecule into two molecules.
  • Both new molecules have the same base sequence as the original: they are exact copies.
  • The base sequence carries the genetic information, so both copies carry the same genes.
  • Replication happens before a cell divides, so each new cell can get a complete copy.
One DNA molecule reading A T G C C A separates into its two strands; a new strand is built on each, giving two molecules that both read A T G C C A
One molecule in, two identical molecules out.
Remember it as: One molecule in, two out, the same sequence in both.

Real example: red blood cells. Your bone marrow makes about 2 million red blood cells every second. Every cell that divides to make them first copies all of its DNA, so the new cells carry the same genes.

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Why copy at all?: Every time a cell divides, each new cell needs a complete, exact copy of the DNA. Cells divide for three reasons.
Three panels: a bacterium splitting into two cells, one cell becoming two then four, and a worn skin cell being lost while a new cell is made below itThree panels: a bacterium splitting into two cells, one cell becoming two then four, and a worn skin cell being lost while a new cell is made below it
Every new cell, for whatever reason it is made, needs a full copy of the DNA.

Reproduction

  • A bacterium copies its DNA, then splits into two new organisms.
  • Cells that make sex cells copy their DNA first too.

Growth

  • A fertilized egg divides again and again.
  • A human body has trillions of cells, all from one.

Tissue replacement

  • Worn-out or damaged cells are replaced.
  • Skin, gut lining and blood are renewed all the time.

Real example: the lining of the gut. The cells lining the small intestine wear away and are replaced every few days. Stem cells at the base of the lining divide constantly, copying their DNA each time, so every new lining cell has the same genes.

Do not mix them up: Replication copies the DNA. Cell division comes after it and shares the two copies between the two new cells.
How it is asked: A short 'outline why DNA is replicated' or 'state what is the same about the copies', often as the first part of a longer replication question.
IB-style questionExplain[3 marks]

Explain why the DNA in the two cells made when a gut lining cell divides must be identical to the DNA of the parent cell.

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Test yourself on DNA replication as production of exact copies of DNA with identical base sequences. Write your answer and get instant AI feedback — just like a real IB examiner.

The small intestine replaces its lining every few days, and a bacterium in the gut divides about every 20 minutes.

why DNA replication is needed in each case.
[2 marks]

Related Biology HL Topics

Continue learning with these related topics from the same unit:

4.1.2Semi-conservative nature of DNA replication and role of complementary base pairing4.1.3Role of helicase and DNA polymerase in DNA replication4.1.4Polymerase chain reaction and gel electrophoresis as tools for amplifying and separating DNA4.1.5Applications of polymerase chain reaction and gel electrophoresis
View all Biology HL topics
Improve your exam techniqueCommand terms, paper structure, and mark-scheme tips for Biology HL
Previous3.9.6Decomposers & nutrient cyclingNextSemi-conservative nature of DNA replication and role of complementary base pairing4.1.2

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